Anaplasma marginale Type IV Secretion System Proteins VirB2, VirB7, VirB11, and VirD4 Are Immunogenic Components of a Protective Bacterial Membrane Vaccine
نویسندگان
چکیده
منابع مشابه
Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine.
Rickettsial pathogens in the genera Anaplasma and Ehrlichia cause acute infection in immunologically naive hosts and are major causes of tick-borne disease in animals and humans. Immunization with purified outer membranes induces protection against acute Anaplasma marginale infection and disease, and a proteomic and genomic approach recently identified 21 proteins within the outer membrane immu...
متن کاملIdentification of Anaplasma marginale Type IV Secretion System Effector Proteins
BACKGROUND Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A. marginale revealed that it has a type IV secretion system (T4SS). The T4SS is one of seven known types of secretion systems utilized by bacteria, with the type III and IV se...
متن کاملTHE IMMUNOGENICITY OF THE TYPE IV SECRETION SYSTEM IN ANAPLASMA MARGINALE By ERIC LYNN SUTTEN
by Eric L. Sutten, M.S. Washington State University August 2009 Chair: Wendy C. Brown Anaplasma marginale is an economically important tick-borne intraerythrocytic rickettsial pathogen of cattle that can cause fever, weight loss and death upon acute infection in naïve hosts. Immunization with isolated outer membrane (OM) fractions elicits protective immunity against infection, whereas immunizat...
متن کاملFunctional interactions of VirB11 traffic ATPases with VirB4 and VirD4 molecular motors in type IV secretion systems.
Pilus biogenesis and substrate transport by type IV secretion systems require energy, which is provided by three molecular motors localized at the base of the secretion channel. One of these motors, VirB11, belongs to the superfamily of traffic ATPases, which includes members of the type II secretion system and the type IV pilus and archaeal flagellar assembly apparatus. Here, we report the fun...
متن کاملDelineation of polar localization domains of Agrobacterium tumefaciens type IV secretion apparatus proteins VirB4 and VirB11
Agrobacterium tumefaciens transfers DNA and proteins to a plant cell through a type IV secretion apparatus assembled by the VirB proteins. All VirB proteins localized to a cell pole, although these conclusions are in dispute. To study subcellular location of the VirB proteins and to identify determinants of their subcellular location, we tagged two proteins, VirB4 and VirB11, with the visual ma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2010
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01207-09